Was ist Revivogen®?
Revivogen® ist ein dermatologisch empfohlenes und auf der Basis von natürlichen Inhaltsstoffen hergestelltes Präparat, das den Haarverlust bei Männern und Frauen signifikant reduziert. Revivogen® wurde von dem bekannten amerikanischen Dermatologen Dr. Alex Khadavi entwickelt, der dabei die wirksamsten Pflanzenextrakte mit nachweislicher Wirkung auf das, die Reduzierung des Haarverlust verursachenden DHT, in einer einzigartigen neuen und wirksamen Formel kombinierte.
"Kostenloses" Travel Kit Frühlingsaktion 2012
Beim Kauf eines der 3 Revivogen-Produkte in Ihrer Stammapotheke erhalten Sie bei Vorlage dieses Gutscheins ein Travel-Kit-Set (jeweils 60 ml Bio-Cleansing-Shampoo und Tickening Conditioner) gratis dazu. Drucken Sie diesen Gutschein aus und legen Sie ihn einfach in Ihrer Apotheke vor.
Revivogen® jetzt mit der neuen patentierten Wirksamkeitsformel direkt bei diamed-depot-system bestellen. Zur europäischen Markteinführung jetzt zum Sonderpreis mit der 90-Tage-Geld-Zurück-Garantie!
Inhaltsstoffe, wissenschaftliche Fakten, Publikationen und Hintergründe
REVIVOGEN® - Wirkung durch Forschung !
Wirksame Inhaltsstoffe von Revivogen® : Die aktiven und
wirksamen Inhaltsstoffe von Revivogen sind vollständig natürliche
Substanzen, die nachweisbar die 5-Alpha-Reduktase (das Enzym das DHT
produziert) inhibieren,
die androgenen Rezeptoren im Haarfollikel blockieren und das
Haarwachstum stimulieren. Diese aktiven Inhaltsstoffe beinhalten
Gamma-Linolensäure (GLA), Alpha-Linolensäure (ALA), Linolensäure,
Ölsäure, Azelainsäure, Vitamin B6, Zink, Sägepalmen-Extrakt (Saw
Palmetto Extract), Beta-Sitosterol und Procyanidin Oligomere.
Revivogen ist das einzige Produkt weltweit, das alle diese gut
beschriebenen Inhaltsstoffe in einer einfach anwendbaren Formel
enthält.
GLA, ALA, Linolensäure und Ölsäure
Gamma-Linolensäure (GLA), Alpha-Linolensäure (ALA), Linolensäure
und Ölsäure sind essentielle Fettsäuren, die man in Pflanzen findet.
Alle diese Fettsäuren wurden einzeln untersucht und ihre Wirkung zur
Inhibierung von 5-Alpha-Reduktase nachgewiesen. Überhaupt sind diese
Substanzen die stärksten Inhibitoren von 5-Alpha-Reduktase, die
heute bekannt sind. Sie unterdrücken dabei nicht nur die Wirkung der
Typ II 5-Alpha-Reduktase, wie zum Beispiel andere Produkte wie
Propecia®, sondern auch noch die Typ I Form des Enzyms, dass in
hohen Konzentrationen auf der Kopfhaut, in Talgdrüsen und in der
Haut gefunden werden kann. Zusätzlich haben GLA, ALA und
Ölsäure eine sehr starke anti-entzündliche Wirksamkeit.
Publikationen
Azelainsäure, Vitamin B6 und Zinksulfat
Azelainsäure ist eine natürlich vorkommende Dicarbonsäure die aus ganzen Getreidekörnern von Roggen und Gerste und aus einigen tierischen Quellen stammt. Sie ist FDA (Food & Drug Administration USA) zugelassen als topisch verwendbares Präparat für die Behandlung von Akne und sehr wirksam gegen eine Reihe anderer Hautkrankheiten. Es gibt starke wissenschaftliche Hinweise, dass Azelainsäure und Zink ebenfalls potente 5-Alpha-Reduktase Inhibitoren sind. Mit der Kombination aus Azelainsäure, Vitamin B6 und Zinksulfat in sehr kleinen Konzentrationen konnte bereits eine 90%ige Inhibierung der Aktivität der 5-Alpha-Reduktase erreicht werden. Die synergistische Wirksamkeit dieser Komponenten gegen 5-Alpha-Reduktase macht diese Kombination als sehr wirksam gegen die männliche Glatzenbildung.
Durch die Kombination von GLA, ALA, Linolensäure, Azelainsäure,
Vitamin B6, Zinksulfat und Sägepalmen-Extrakt haben wir also eine
natürliche und sehr effektive Anti-DHT Formel kreiert. Die
Einzelsubstanzen wirken zwar unterschiedlich, haben aber einen
synergistischen Effekt um die Typ I und Typ II Formen der
5-Alpha-Reduktase zu inhibieren und dadurch DHT lokal zu reduzieren.
Durch die Reduktion des DHT Levels können Haar besser und voller
wachsen, einen vollen Haarwuchs bewirken und das alles ohne die
bekannten Nebenwirkungen von synthetischen Pharmazeutika.
Publikationen
Sägepalmen-Extrakt
(Serenoa repens)
Sägepalmen Extrakt wurde in den letzten Jahren sehr gründlich untersucht, um damit Prostata Beschwerden bei Männern zu behandeln. Sägepalmen Extrakt, bekannt für seine anti-androgene Wirkung, ist der fettlösliche Extrakt aus der Frucht der Sägepalme.
Sägepalmen Extrakt konnte in Studien die Bildung von DHT
blockieren und es scheint wahrscheinlich, dass es auch die Androgen
Rezeptoren im Haarfollikel blockieren kann. Genauso wie GLA und ALA
blockiert es auch die Typ I und II Formen der 5-Alpha Reduktase und
zeigte dabei deutlich mehr Wirkung als Finasterid, der wirksame
Bestandteil von Propecia.
Publikationen
Procyanidin Oligomere
Procyanidin Oligomere, die auch als Pro-Anthocyanidine) bekannt
sind, sind aus der Natur gewonnene Wirkstoffe, die eine ähnlich
stimulierende Wirkung auf das Haarwachstum haben wie Minoxidil (Regaine®).
In neueren Studien haben japanische Forscher nachgewiesen, dass
Procyanidin Oligomere einen stimulierenden Effekt auf Haar-Epithel
Zellen in vitro haben und die Anagen Induktion der Haarfollikel in
vivo stimulieren. Der Zusatz von Procyanidin Oligomeren zur
Revivogen Formel soll also das Haarwachstum anregen.
Publikationen
Wissenschaftliche Publikationen
Gamma Linolensäure, Alpha Linolensäure und Linolensäure
In den nachfolgenden Studien wurde der inhibitorische Effekt auf
die Typ I und II Form der 5-Alpha-Reduktase und damit auf die
Reduzierung des
Dehydrotestosterons (DHT) untersucht, den Gamma Linolensäure, Alpha
Linolensäure und Linolensäure bei topischer Applikation bewirken.
Auffällig daran besonders der gute Effekt ohne irgendwelche
systemischen Nebeneffekte. Die Studien belegen weiterhin, das diese
Fettsäuren besonders wirksam sind bei durch DHT ausgelöste Störungen
des Haarwachstums insbesondere männliche Glatzenbildung, Akne und
starke Formen des weiblichen Haarwachstums (Hirsutismus).
Studie B: Androgen action: molecular
mechanism and medical application.
Studie C: Inhibition of steroid 5 alpha-reductase by specific
aliphatic unsaturated fatty acids.
Azelainsäure, Vitamin B6 und Zinksulfat
Diese Artikel wurde im British Journal of Dermatology publiziert und demonstriert die synergistische Wirksamkeit von Azelainsäure, Zinksulfat und Vitamin B6 die schon in kleinen Mengen die 5-Alpha-Reduktase um 90% inhibieren.
Studie A : Inhibition of 5alpha-reductase activity in human
skin by zinc and Azelaic acid.
Sägepalmen-Extrakt (Serenoa repens)
In den folgenden Studien wurde nachgewiesen, dass Sägepalmen-Extrakt sowohl die Typ I als auch die Typ II Form der 5-Alpha-Reduktase inhibiert (Finasterid und Propecia inhibieren nur die Typ II Form). Dabei war der Extrakt wirksamer als Finasterid und reduzierte die Bindung von Testosteron und DHT an verschiedene Gewebetypen effektiv. Bitte beachten Sie, dass in den aufgeführten Studien der Sägezahn Extrakt zum Teil als Permixon oder lipid-sterol extract of Serenoa repens (LSESr) bezeichnet wird.
Studie C : The effect of Permixon on androgen receptors.
In den unten geannten Studien wurde gezeigt, das Procyanidin Oligomere das Haarwachstum aktivieren konnten.
Wissenschaftliche Publikationen Original (englisch)
AUTHOR
Liang T; Liao S
JOURNAL
Journal of Investigational Dermatology: 1997 Aug; 109 (2): 152-7
ABSTRACT
Certain unsaturated aliphatic fatty acids, such as gamma-linolenic acid, inhibit 5alpha-reductase activity in vitro and in vivo. Hamster flank organ growth, as measured by the increase in the area of pigmented macule, is dependent on androgen. When one of the paired flank organs of a castrated hamster was treated topically with testosterone, the treated organ, but not the contralateral flank organ, became larger and darker. Topical application of gamma-linolenic acid to the testosterone-treated flank organ suppressed this testosterone effect. Other fatty acids that were not inhibitors of 5alpha-reductases were not active. Topical treatment of hamster flank organs with 5alpha-dihydrotestosterone also stimulated the growth of the organ. This 5alpha-dihydrotestosterone-dependent activity, however, was not significantly affected by gamma-linolenic acid, suggesting that flank organ growth was dependent on 5alpha-dihydrotestosterone and that gamma-linolenic acid acted by inhibiting 5alpha-reductase. With intact male hamsters, the endogenous androgen-dependent growth of flank organs is also suppressed by topical treatment with gamma-linolenic acid. The effect of gamma-linolenic acid is localized at the site of its application; topical application of gamma-linolenic acid did not affect the androgen-dependent growth of other organs such as testis, epididymis, seminal vesicle, and prostate. gamma-Linolenic acid, with low toxicity and absence of systemic effect, therefore may be potentially useful for treatment of androgen-dependent skin disorders.
Nach Oben
STUDY B: Androgen action: molecular mechanism and medical application.
AUTHOR
Liao S
JOURNAL
Journal of Formos Medical Association: 1994 Sep; 93 (9): 741-51
ABSTRACT
Androgen action in many organs, such as prostate and skin, is dependent on the conversion of testosterone by 5 alpha-reductase to 5 alpha-dihydrotestosterone. 5 alpha-Dihydrotestosterone then binds to the androgen receptor to regulate specific gene expression. Inhibitors of 5 alpha-reductase are useful for the selective treatment of prostatic cancer, benign prostate hyperplasia, acne, baldness and female hirsuitism, without affecting spermatogenesis, sexual behavior and smooth muscle growth, that do not require the conversion of testosterone to 5 alpha-dihydrotestosterone. Certain unsaturated fatty acids, such as gamma-linolenic acid, are potent 5 alpha-reductase inhibitors, suggesting a linkage between unsaturated fatty acids and androgen action. Mutations in androgen receptor genes are responsible for many cases of androgen-insensitivity. In some prostate cancer cells, some antiandrogens may act like androgens in stimulating the proliferation of the cancer cells because these antiandrogens can bind to a mutated androgen receptor and transactivate target genes. Prostate cancers are usually androgen-dependent initially but can lose dependency and responsiveness. Tumor cells which are resistant to endocrine therapy ultimately proliferate. Androgen-independent or androgen-repressive cells can arise from androgen-sensitive prostate cancer cells by changes in specific gene expression over time in a clonal isolate. This change in androgen responsiveness was accompanied by a change in androgen receptor expression and transcriptional activity as well as expression of some oncogenes.
Nach Oben
STUDY C: Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids.
AUTHOR
Liang T; Liao S
JOURNAL
Journal of Biochemistry, 1992 Jul 15, 285 ( Pt 2):, 557-62
ABSTRACT
Human or rat microsomal 5 alpha-reductase activity, as measured by enzymatic conversion of testosterone into 5 alpha-dihydrotestosterone or by binding of a competitive inhibitor, [3H]17 beta-NN-diethulcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one ([3H]4-MA) to the reductase, is inhibited by low concentrations (less than 10 microM) of certain polyunsaturated fatty acids. The relative inhibitory potencies of unsaturated fatty acids are, in decreasing order: gamma-linolenic acid greater than cis-4,7,10,13,16,19-docosahexaenoic acid = cis-6,9,12,15-octatetraenoic acid = arachidonic acid = alpha-linolenic acid greater than linoleic acid greater than palmitoleic acid greater than oleic acid greater than myristoleic acid. Other unsaturated fatty acids such as undecylenic acid, erucic acid and nervonic acid, are inactive. The methyl esters and alcohol analogues of these compounds, glycerols, phospholipids, saturated fatty acids, retinoids and carotenes were inactive even at 0.2 mM. The results of the binding assay and the enzymatic assay correlated well except for elaidic acid and linolelaidic acid, the trans isomers of oleic acid and linoleic acid respectively, which were much less active than their cis isomers in the binding assay but were as potent in the enzymatic assay. gamma-Linolenic acid had no effect on the activities of two other rat liver microsomal enzymes: NADH:menadione reductase and glucuronosyl transferase. gamma-Linolenic acid, the most potent inhibitor tested, decreased the Vmax. and increased Km values of substrates, NADPH and testosterone, and promoted dissociation of [3H]4-MA from the microsomal reductase. gamma-Linolenic acid, but not the corresponding saturated fatty acid (stearic acid), inhibited the 5 alpha-reductase activity, but not the 17 beta-dehydrogenase activity, of human prostate cancer cells in culture. These results suggest that unsaturated fatty acids may play an important role in regulating androgen action in target cells.
Nach Oben
STUDY A: Inhibition of 5alpha-reductase activity in human skin by zinc and Azelaic acid.
AUTHOR
Stamatiadis, D; Bulteau-Portois, MC; Mowszowicz, I.
JOURNAL
British Journal of Dermatology, 1988 Nov, 119(5):627-32.
ABSTRACT
The effects of zinc sulfate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5-alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc, but not of azelaic acid, suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulfate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.
Nach Oben
STUDY A: Human prostatic steroid 5 alpha-reductase isoforms--a comparative study of selective inhibitors.
This study suggests that Fenistride (active ingredient of Propecia) only inhibited the Type 2 form of 5 alpha reductase where Saw Palmetto extract inhibited both type 1 and 2 forms of 5 alpha-reductase and was more potent than Fenistride.
AUTHOR
Iehlé C; Délos S; Guirou O; Tate R; Raynaud JP; Martin PM
JOURNAL
J Steroid Biochem Mol Biol, 54: 5-6, 1995 Sep, 273-9
ABSTRACT
The present study describes the independent expression of the type 1 and 2 isoforms of human 5 alpha-reductase in the baculovirus-directed insect cell expression system and the selectivity of their inhibition. The catalytic properties and kinetic parameters of the recombinant isozymes were consistent with published data. The type 1 isoform displayed a neutral (range 6-8) pH optimum and the type 2 isoform an acidic (5-6) pH optimum. The type 2 isoform had higher affinity for testosterone than did the type 1 isoform (Km = 0.5 and 2.9 microM, respectively). Finasteride and turosteride were selective inhibitors of the type 2 isoform (Ki (type 2) = 7.3 and 21.7 nM compared to Ki (type 1) = 108 and 330 nM, respectively). 4-MA and the lipido-sterol extract of Serenoa repens (LSESr) markedly inhibited both isozymes (Ki (type 1) = 8.4 nM and 7.2 micrograms/ml, respectively; Ki (type 2) = 7.4 nM and 4.9 micrograms/ml, respectively). The three azasteroids were competitive inhibitors vs substrate, whereas LSESr displayed non-competitive inhibition of the type 1 isozyme and uncompetitive inhibition of the type 2 isozyme. These observations suggest that the lipid component of LSESr might be responsible for its inhibitory effect by modulating the membrane environment of 5 alpha-reductase. Partially purified recombinant 5 alpha-reductase type 1 activity was preserved by the presence of lipids indicating that lipids can exert either stimulatory or inhibitory effects on human 5 alpha-reductase.
Nach Oben
This Study shows that Fenistride and 4-MA inhibited the formation of some testostrone Metabolites (including DHT), where as Saw Palmetto inhibited the formation of all the Testostrone metabolites studied.
AUTHOR
Délos S; Carsol JL; Ghazarossian E; Raynaud JP; Martin PM
JOURNAL
J Steroid Biochem Mol Biol, 55: 3-4, 1995 Dec, 375-83
ABSTRACT
We compare testosterone (T) metabolism in primary cultures of epithelial cells and fibroblasts separated from benign prostate hypertrophy (BPH) and prostate cancer tissues. In all cultures, androstenedione (delta 4) formed by oxidation of T by 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) represented 80% of the metabolites recovered. The amounts of 5 alpha-dihydrotestosterone (DHT), formed by reduction of T by 5 alpha-reductase (5 alpha-R), were small: 5 and 2% (BPH) and 8 and 15% (adenocarcinoma) for epithelial cells and fibroblasts, respectively. Northern blot analysis of total RNA from epithelial cells (BPH or adenocarcinoma) attributed the reductive activity to the 5 alpha-reductase type 1 isozyme and oxidative activity to the 17 beta-HSD type 2. In cancer fibroblasts, only little 17 beta-HSD type 2 mRNA was detected. The 5 alpha-reductase inhibitors, 4-MA (17 beta-(N,N-diethyl)carbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one) and finasteride, inhibited DHT formation with a preferential action of 4-MA on epithelial cells (BPH or adenocarcinoma) and of finasteride on fibroblasts from adenocarcinoma. Neither inhibitor acted on delta 4 formation. On the other hand, the lipido-sterol extract of Serenoa repens (LSESr, Permixon, Saw Palmetto) inhibited the formation of all the T metabolites studied [IC50 S = 40 and 200 micrograms/ml (BPH) and 90 and 70 micrograms/ml (adenocarcinoma) in epithelial cells and fibroblasts, respectively]. These results have important therapeutic implications when selecting appropriate treatment options for BPH.
Nach Oben
STUDY C: The effect of Permixon on androgen receptors.
This study shows that Saw Palmetto extract was able to effectively reduce Binding of Testostrone and DHT to their receptors on various tissues.
AUTHOR
el-Sheikh MM; Dakkak MR; Saddique A
JOURNAL
Acta Obstet Gynecol Scand, 67: 5, 1988, 397-9
ABSTRACT
Permixon, the liposterolic extract of the plant Serenoa Repens is a recently introduced drug for the treatment of benign prostatic hyperplasia. The effect of Permixon on dihydrotestosterone and testosterone binding by eleven different tissue specimens was tested. The drug reduced the mean uptake of both hormones by 40.9% and 41.9% respectively in all tissue specimens. Since hirsutism and virilism are among other gynecological problems caused either by excessive androgen stimulation or excess endorgan response, we suggest that Permixon could be a useful treatment in such conditions and recommend further investigations of the possible therapeutic values of the drug in gynecological practice.
Nach Oben
J Invest Dermatol 1999 Mar;112 (3):310-6
Takahashi T, Kamiya T, Hasegawa A, Yokoo Y
Tsukuba Research Laboratories, Kyowa Hakko Kogyo, Ibaraki, Japan.
We have previously reported that proanthocyanidins extracted from grape seeds possess growth-promoting activity toward murine hair epithelial cells in vitro and stimulate anagen induction in hair cycle progression in vivo. This report constitutes a comparison of the growth-promoting activity of procyanidin oligomers and the target cells of procyanidins in the skin. Results show that procyanidin dimer and trimer exhibit higher growth-promoting activity than the monomer. The maximum growth-promoting activity for hair epithelial cells with procyanidin B-2, an epicatechin dimer, reached about 300% (30 microM) relative to controls (= 100%) in a 5 d culture. Optimum concentration of procyanidin C-1, an epicatechin trimer, was lower than that of procyanidin B-2; the maximum growth-promoting activity of procyanidin C-1 was about 220% (3 microM). No other flavonoid compounds examined exhibit higher proliferative activities than the procyanidins. In skin constituent cells, only epithelial cells such as hair keratinocytes or epidermal keratinocytes respond to procyanidin oligomers. Topical application of 1% procyanidin oligomers on shaven C3H mice in the telogen phase led to significant hair regeneration [procyanidin B-2, 69.6% +/- 21.8% (mean +/- SD); procyanidin B-3, 80.9% +/- 13.0%; procyanidin C-1, 78.3% +/- 7.6%] on the basis of the shaven area; application of vehicle only led to regeneration of 41.7% (SD = 16.3%). In this paper, we demonstrate the hair-growing activity of procyanidin oligomers both in vitro and in vivo, and their potential for use as agents to induce hair growth.
PMID: 10084307, UI: 99181798
Nach Oben
Acta Derm Venereol 1998 Nov;78(6):428-32
Takahashi T, Kamiya T, Yokoo Y
Tsukuba Research Laboratories, Kyowa Hakko Kogyo Co., Ibaraki, Japan.
For the purpose of discovering natural products which possess hair growing activity, we examined about 1000 kinds of plant extracts concerning growth-promoting activity with respect to hair follicle cells. After an extensive search, we discovered that proanthocyanidins extracted from grape seeds promote proliferation of hair follicle cells isolated from mice by about 230% relative to controls (100%); and that proanthocyanidins possess remarkable hair-cycle-converting activity from the telogen phase to the anagen phase in C3H mice in vivo test systems. The profile of the active fraction of the proanthocyanidins was elucidated by thiolytic degradation and tannase hydrolysis. We found that the constitutive monomers were epicatechin and catechin; and that the degree of polymerization was 3.5. We demonstrated the possibility of using the proanthocyanidins extracted from grape seeds as agents inducing hair growth.
PMID: 9833041, UI: 99050235
Nach Oben